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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MAPK12 All Species: 13.64
Human Site: Y59 Identified Species: 25
UniProt: P53778 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P53778 NP_002960.2 367 41940 Y59 K V A I K K L Y R P F Q S E L
Chimpanzee Pan troglodytes Q95NE7 360 41475 F59 V K K L S R P F Q S I I H A K
Rhesus Macaque Macaca mulatta XP_001112462 367 41940 Y59 K V A I K K L Y R P F Q S E L
Dog Lupus familis XP_848658 287 32890 D20 F T P D E T L D D F T D F Y L
Cat Felis silvestris
Mouse Mus musculus O08911 367 42025 Y59 K V A I K K L Y R P F Q S E L
Rat Rattus norvegicus Q63538 367 41967 Y59 K V A I K K L Y R P F Q S E L
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001509537 374 42522 F60 I K K L S R P F Q S E I F A K
Chicken Gallus gallus XP_001233062 310 36087 V43 L D V F T P D V T L E K F N G
Frog Xenopus laevis P47812 361 41700 F60 V K K L S R P F Q S I I H A K
Zebra Danio Brachydanio rerio O42376 363 41952 F60 I K K L H R P F Q S D L F A K
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster O61443 365 42080 F59 I K K L A R P F Q S A V H A K
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q17446 377 43900 N67 R V A I K K F N R P F Q S I I
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa Q96TL5 358 41225 V59 M K P F S T P V L A K R T Y R
Conservation
Percent
Protein Identity: 100 61.8 99.1 74.1 N.A. 92.6 93.7 N.A. 66.5 65.4 60.2 67.8 N.A. 56.9 N.A. 54.6 N.A.
Protein Similarity: 100 77.6 99.1 75.7 N.A. 95.9 96.1 N.A. 77.5 76.5 76.5 81.7 N.A. 73.8 N.A. 72.1 N.A.
P-Site Identity: 100 0 100 13.3 N.A. 100 100 N.A. 0 0 0 0 N.A. 0 N.A. 66.6 N.A.
P-Site Similarity: 100 26.6 100 20 N.A. 100 100 N.A. 26.6 6.6 26.6 26.6 N.A. 26.6 N.A. 80 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. 46.5
Protein Similarity: N.A. N.A. N.A. N.A. N.A. 65.4
P-Site Identity: N.A. N.A. N.A. N.A. N.A. 0
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. 13.3
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 39 0 8 0 0 0 0 8 8 0 0 39 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 8 0 8 0 0 8 8 8 0 8 8 0 0 0 % D
% Glu: 0 0 0 0 8 0 0 0 0 0 16 0 0 31 0 % E
% Phe: 8 0 0 16 0 0 8 39 0 8 39 0 31 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8 % G
% His: 0 0 0 0 8 0 0 0 0 0 0 0 24 0 0 % H
% Ile: 24 0 0 39 0 0 0 0 0 0 16 24 0 8 8 % I
% Lys: 31 47 39 0 39 39 0 0 0 0 8 8 0 0 39 % K
% Leu: 8 0 0 39 0 0 39 0 8 8 0 8 0 0 39 % L
% Met: 8 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 8 0 0 0 0 0 8 0 % N
% Pro: 0 0 16 0 0 8 47 0 0 39 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 39 0 0 39 0 0 0 % Q
% Arg: 8 0 0 0 0 39 0 0 39 0 0 8 0 0 8 % R
% Ser: 0 0 0 0 31 0 0 0 0 39 0 0 39 0 0 % S
% Thr: 0 8 0 0 8 16 0 0 8 0 8 0 8 0 0 % T
% Val: 16 39 8 0 0 0 0 16 0 0 0 8 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 31 0 0 0 0 0 16 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _